DISCLAIMER: This page is transferred from the PARENCHIMA archives and needs updating.
Inventory of clinical studies in renal MRI
This inventory provides a list of ongoing or completed clinical studies involving MRI of the kidney. The list was compiled by PARENCHIMA working group 3 and continues to be maintained. Initial data were collected from working group members and through individual contact with external researchers. The inventory is dynamic and will continue to be updated and maintained as new studies are started, or ongoing studies are closed.
The inventory is currently being revised to include the most up to date information. For ongoing studies, investigators are asked to provide a clinical trial registration number and/or a link to a published study protocol. For studies that are not yet recruiting, a link to the award is sufficient. For completed studies, investigators will be asked to provide a link to a publication reporting on the primary outcome. Studies that are not able to provide these informations will be removed from the inventory.
For any comments, corrections or additions, please refer to the following contacts:
All application areas except ADPKD and Transplantation: contact the working group 3 lead. ADPKD studies: contact the ADPKD task force lead. Renal transplantation studies: contact the Transplantation Task force lead. Notations used:
P = Prospective, R = Retrospective O = Observational, I = Interventional
Ongoing multi-centre studies (excluding ADPKD and Transplantation)
| Study name | Clinical area | N. patients | Study type | Protocol / registration | Principal investigator/ Contact person |
|---|---|---|---|---|---|
| iBEAt | DKD | 500 T2D, 50 T1D | P, O | Protocol paper | Prof. Steven Sourbron |
| HEROIC | DKD | 500 | P, O | Protocol paper | Dr Kieran Mccafferty |
| AFiRM | CKD | 450 | P, O | Award | Prof. Nicholas Selby |
| EMPA_KIDNEY MRI sub-study | CKD | 60 | P, I | Registration | Prof. Richard Haynes |
| DWI for kidney cortical intersitial fibrosis prediction | Renal transplantation | 250 | P, O | MISSING | Prof Jean-Paul Vallee |
Ongoing single-centre studies (excluding ADPKD and Transplantation)
| Study | Clinical area | N. patients | Study type | Main
info |
Principal investigator/
Contact person |
|---|---|---|---|---|---|
| SUGAR | Heart failure, Diabetes | 105 | Prospective, Interventional (Empagliflozin) | Link | Prof. Naveed Sattar |
| AM-01 | DKD | 66 | Prospective, Observational |
|
Dr Seema Baid-Agrawal
Dr Paul Hockings |
| Advanced MRI for improved diagnosis and prediction of treatment response in Wilms’ tumour patient | Wilms' tumour | 110 | Prospective, Observational |
|
Dr Chris Clark |
| Renal diffusion in CKD | CKD | 150 | Prospective, Observational |
|
Dr Jean-Paul Vallée |
| ReMARK | Healthy volunteers | 20 | Prospective, Observational |
|
Dr Anneloes de Boer |
| ReFINED | CKD, hypertension, healthy volunteers | 10/10/15 | Prospective, Observational |
|
Dr Anneloes de Boer |
| Role of digital pathology and MRI in the early detection of interstitial fibrosis in CKD | CKD (both native and transplanted kidneys) | 75 | Prospective, Observational |
|
Dr Carlos Nicolau |
| Gender-BOLD | CKD and controls | 110 | Prospective, Observational |
|
Dr Menno Pruijm |
| Functional MRI in the diagnostics of diabetic nephropathy in patients with type 2 DM | DKD | 90 | Prospective, Observational |
|
Dr Olivera Nikolic |
| ACH471-205
MRI sub-study |
C3G -
IC-MPGN rare disease |
7 | Prospective, Interventional (ACH-0144471) | Link | Dr Anna Caroli |
| ROCKIES | Diabetes | 40 (T2D and healthy controls) | Prospective, Interventional
(Ertugliflozin) |
Link | Dr Daniel van Raalte |
| GCKD MRI sub-study | CKD | 30 | prospective, observational |
|
Prof. Dr. K. U. Eckardt / Dr. Maurice Heimer |
| Improvement of diagnostics of myeloma specific renal changes by functional MRI-biomarkers | multiple myeloma | 40 patients, 10 healthy volunteers | prospective, observational |
|
Dr Alexandra Ljimani |
| Renal pathologies in rheumatological diseases: Improvement of diagnostics using functional magnetic resonance imaging | Lupus | 30 | prospective, observational |
|
Dr Alexandra Ljimani |
| Quantitative magnetization transfer MRI for evaluation of renal fibrosis | Renovascular disease | 15 | prospective, observational | Link | Prof. Lilach O. Lerman |
| Advanced diffusion imaging for management of renal cancer: oncologic control and renal functional reserve | Renal cancer | 24 healthy controls, 150 renal mass patients | prospective, observational | Link | Dr Eric Sigmund
Dr Hersh Chandarana |
| Role of MMP-10 and tissue perfusion in diagnosis and prognosis of renal and cardiovascular disease in patients with 2 type diabetes mellitus | Diabetes | 70 with MRI (268 in total) | prospective, observational |
|
Dr Nuria García Fernández |
| Quantitative susceptible imaging of the human kidney on a clinical MRI system | Mixed | 20 renal patients, 10 healthy volunteers | prospective, observational |
|
Dr Alexandra Ljimani |
| Evaluation of CT-contrast agent induced ATN by functional renal MR-imaging | CT-contrast agent induced ATN | 40 | prospective, observational |
|
Dr Alexandra Ljimani |
| Evaluation of renal damage after a SARS-CoV-2 infection using functional, contrast-free kidney MRI | COVID-19 | 30 | prospective, observational |
|
Dr Alexandra Ljimani |
| MAGNA VICTORIA study
|
T2DM patients and healthy controls
|
150 | prospective, interventional (liraglutide) | Protocol1
Protocol2 |
Dr Ilona Dekkers
Prof Dr Hiddo J Lamb |
| NEO study | Obesity | 2500 | prospective, observational | Link
|
Dr Ilona Dekkers
Prof Dr Hiddo J Lamb |
Completed studies (excluding ADPKD and Transplantation)
| Study | Clinical area | N. patients | Study type | Main
info |
Principal investigator/
Contact person |
|---|---|---|---|---|---|
| REMIND-CKD | CKD | 26 | prospective, observational | Link | Prof. Nicholas Selby |
| REMIND-AKI | AKI | 10 | prospective, observational |
|
Prof. Nicholas Selby |
| Effects of the SGLT-2 Inhibitor Empagliflozin on Renal Tissue Oxygenation in Non-Diabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Study Protocol. | healthy volunteers (non-diabetic subjects) | 15 normal weight, 15 overweight, 15 obese | prospective, interventional (Empagliflozin) | Link | Dr Menno Pruijm |
| Renal NCE-MRI in Healthy Volunteers | healthy volunteers | 16 | prospective, observational | Link | Dr Anna Caroli |
| Renal DCE-MRI in healthy volunteers comparing two imaging sequences (FLASH/KWIC) and use of iohexol clearance as clinical reference test | healthy volunteers | 10 | prospective, observational |
|
Dr Eli Eikefjord |
| Test-retest renal DCE-MRI in healthy volunteers and use of iohexol clearance as clinical reference test | healthy volunteers | 20 | prospective, observational |
|
Dr Eli Eikefjord |
| Renal DCE-MRI in living kidney donors | Kidney donors | 20 | prospective, observational |
|
Dr Eli Eikefjord |
| Renal pCASL Repeatability/Reproducibility Study | healthy volunteers | 10 | prospective, observational |
|
Dr Doug Pendse |
| MRI in healthy volunteers | healthy volunteers | 7 | prospective, observational |
|
Dr Isky Gordon |
| MRI reproducibility in healthy volunteers | healthy volunteers | 16 | prospective, observational |
|
Dr Isky Gordon |
| MRI in paediatric CKD | paediatric CKD | 11 | prospective, observational |
|
Dr Isky Gordon |
| Reproducibility of Single Kidney GFR with DCE-MRI in healthy volunteers | healthy volunteers | 34 | prospective, observational |
|
Dr Isky Gordon |
| DWI in healthy volunteers | healthy volunteers | 10 | prospective, observational |
|
Dr Paul Summers |
| DCE-MRI in renal pathology | mixed renal pathology | 30 | prospective, observational |
|
Dr Paul Summers |
| Renden | resistant hypertension | 75 | prospective, observational |
|
Dr Anneloes de Boer |
| EnCORED: renal artery and parenchymal changes after RDN | therapy resistant hypertension | 96 | prospective, interventional (RDN) |
|
Dr Anneloes de Boer |
| Influence of RAAS inhibition; determine the influence of RAAS inhibition on kidney oxygenation | CKD, healthy volunteers | 10 CKD patients, 5 healthy volunteers | prospective, interventional (RAAS inhibitors) |
|
Dr Anneloes de Boer |
| LauBOLD | CKD, hypertension, healthy volunteers | 224 | prospective, observational |
|
Dr Menno Pruijm |
| 4R01DK093793-05: Longitudinal Changes in the Intra-Renal Oxygenation by BOLD MRI in patients with CKD | CKD, healthy | 66 | prospective, observational | Link | Dr Pottumarthi Prasad |
| 5R21DK079080-02: The intra-renal oxygenation in CKD as evaluated by BOLD-MRI | CKD, healthy | 45 | cross-sectional, observational | Link | Dr Pottumarthi Prasad |
| CKD Optimal Management with Binders and Nicotinamide
(COMBINE) |
CKD | 122 | prospective, interventional (nicotinamide and lanthanum carbonate) | Link | Dr Anand Srivastava |
| Role of MMP-10 and tissue perfusion in nephropathy associated to type 2 diabetes mellitus: clinical and experimental study | Diabetes | 45 controls and 44 T2DM patients with MRI (111 and 268 in total) | prospective, observational | Link | Dr Nuria García Fernández |
Ongoing studies in ADPKD
| Study | Center | N patients | Study type | MR sequences (besides anatomical) | Main info | Contact person |
|---|---|---|---|---|---|---|
| MR-Progression-Evaluation of Chronic Kidney Disease | Medical University of Vienna, Austria | 90 early stage ADPKD, 30 healthy controls | Observational | T1&T2 mapping, DWI/DTI, MRE | DRKS-ID: DRKS00015866 | Dr Marcos Wolf |
| Functional MRI in ADPKD | Universitair Ziekenhuis Brussel, Belgium | 30
|
Observational | DCE |
|
Dr Patricia van der Niepen |
| PKD – imaging the genomic derangements with ultra-sensitive metabolic MRI | Aarhus University Hospital, Denmark | 40 | Interventional | spsp-SPIRAL, T1&T2 mapping, DWI, BOLD, pCASL |
|
Dr Christoffer Laustsen |
| Multiparametric MRI to detect, quantify and predict prognosis of ADPKD | Haukeland University Hospital/University of Bergen, Norway | 30 ADPKD patients, 12 non-ADPKD subjects | Observational | DWI/DTI, BOLD, T1&T2 mapping, ASL |
|
Dr Eli Eikefjord |
| TOOL | Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy | 20 | Interventional (Tolvaptan Plus Octreotide LAR Combination) | DWI, PC-MRI | Link | Dr Anna Caroli |
| Renal fibrosis, microRNA and cardiovascular risk in ADPKD: effect of tolvaptan therapy | Sapienza University, Rome, Italy | 30+30 | Interventional (Tolvaptan) | DCE |
|
Dr Silvia Lai |
| STAGED-PKD | 77 centers (USA, Japan, Germany/Austria) | 640 | Interventional (venglustat) |
|
EudraCT number: 2017-004084-12
Link |
Sanofi |
| Imaging to define disease progression in ADPKD | University of Sheffield and Sheffield Kidney Institute, Sheffield, UK | 35 | prospective, observational |
|
|
Dr Rosylin Simms |
Completed studies in ADPKD
| Study | Center | N. patients | Study type | MR sequences (besides anatomical) | Main
info |
Contact person |
|---|---|---|---|---|---|---|
| EUROCYST | 13 centers around Europe
(DWI substudy: Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy) |
~ 600
(DWI subgroup - 15) |
prospective, observational | anatomical (all patients),
DWI (subgroup) |
Link | Dr Anna Caroli (DWI subgroup) |
| Functional kidney MRI to identify novel biomarkers of disease progression in ADPKD | University of Sheffield and Sheffield Kidney Institute, Sheffield, UK | 29 | prospective, observational | T2*, DWI, DTI, PC-MRI |
|
Dr Rosylin Simms |
| Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease
|
Sapienza, University of Rome, UOC Nephrology,
Policlinico Umberto I Hospital |
27 | prospective, observational | DCE-MRI |
|
Dr Silvia Lai |
| Magnetic resonance imaging 3T and total fibrotic volume in autosomal dominant polycystic kidney disease. | Sapienza, University of Rome, UOC Nephrology,
Policlinico Umberto I Hospital |
15 | prospective, observational | DCE-MRI |
|
Dr Silvia Lai |
Ongoing studies in Transplantation
| Study | Center | N. Patients | Study type | MR sequences (besides anatomical) | Main info | Contact person |
|
Risk factor evaluation for inferior outcome after kidney transplantation by assessment of renal pathophysiology with functional MRI in correlation with molecular markers
|
Hannover Medical School, Germany
|
26
|
observational
|
T2 TSE, T1, ASL, DWI, DTI, T1-Map
|
|
|
|
Artificial intelligence-based analysis of MRI biomarkers to detect allograft dysfunction after kidney transplantation
|
Hannover Medical School, Germany
|
200
|
observational
|
T2 TSE, T1, ASL, DWI, DTI, T1-Map, BOLD
|
|
|
|
Longitudinal evaluation of renal allograft function after transplantation using ASL and IVIM
|
Clínica Universidad de Navarra, Spain
|
40 transplanted patients, 20 controls (eGFR>60)
|
observational
|
T1 VIBE, T2 HASTE, ASL, IVIM
|
|
|
| TransRASL |
University of Glasgow, UK
|
20
|
observational
|
T1 Map, ASL, T2*, DWI, DTI
|
|
|
| diffusion MRI for kidney cortical intersitial fibrosis prediction | University of Geneve, Switzerland | 246 (both native and transplant) | observational | RESOLVE (DWI), T1, T2 |
|
Dr Jean-Paul Vallee |
| ACRADYS | University Medical Center Utrecht, the Netherlands | 50 | observational | BOLD, ASL, DTI |
|
Dr Anneloes de Boer |
| Multicentric Study of diffusion MRI for kidney cortical intersitial fibrosis prediction | University of Geneve. University of Lausanne, Fribourg Hospital; Switzerland | 250 | observational | RESOLVE (DWI), T1, T2 |
|
Dr Jean-Paul Vallee, Dr Menno Pruijm, Prof Harriet Thoeny |
| Artificial intelligence-based analysis of MRI biomarkers to detect allograft dysfunction after kidney transplantation |
Hannover Medical School, Germany; University Medical Center Groeningen, the Netherlands
|
200 renal transplant patients, 50 living donors
|
observational
|
ASL, DWI, IVIM, DTI, T1/T2 mapping, BOLD |
|
|
| Noninvasive Evaluation of Renal Allograft Fibrosis by MRI | Kidney transplant recipients | 20 | prospective, observational | MT, B1, B0, T1 mapping, DWI, BOLD, and ASL |
|
Prof. Lilach O. Lerman |
Completed studies in Transplantation
| Study | Center | N. patients | Study type | MR sequences (besides anatomical) | Main
info |
Contact person |
|---|---|---|---|---|---|---|
| Donor transplant assessment | Institute of Child Health, London, UK | 8 | prospective, observational | ASL, BOLD, DWI, T1 |
|
Dr Isky Gordon |
| Longitudinal study of children following renal replacement therapy | Institute of Child Health, London, UK | 20 | prospective, observational | ASL, BOLD, DWI, T1 |
|
Dr Isky Gordon |
| Observational study in renal transplants | University of Glasgow, UK | 20 | prospective, observational | ASL, T1, DTI, BOLD |
|
Dr Paddy Mark |
| Biexponential analysis of DWI: comparison of three different calculation methods in transplanted kidneys | Uniklinik Duesseldorf Germany | 15 | prospective, observational | DWI | Link | |
| Correlation of biexponential diffusion parameters with ASL perfusion MRI: results in transplanted kidneys | Uniklinik Duesseldorf Germany | 17 | prospective, observational | DWI, ASL | Link | |
| Kidney transplant: functional assessment with DTI at 3T | Uniklinik Duesseldorf Germany | 40 | prospective, observational | DTI | Link | |
| Diffusion-attenuated MRI signal of renal allografts: comparison of two different statistical models | Uniklinik Duesseldorf Germany | 23 | prospective, observational | DWI/DTI | Link | |
| T2' Imaging of Native Kidneys and Renal Allografts - a Feasibility Study | Uniklinik Duesseldorf Germany | 24 | prospective, observational | T2 mapping | Link | |
| Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results | Uniklinik Duesseldorf Germany | 20 | prospective, observational | T2 mapping, ASL | Link | |
| Functional MRI of transplanted kidneys using diffusion-weighted imaging | Uniklinik Duesseldorf Germany | 41 | prospective, observational | DWI |
|
|
| Functional multiparametric MRI in delayed graft function after kidney Transplantation | Hannover Medical School | 70 | prospective, observational | ASL, DWI, DTI, T2 mapping |
|
|
| Integrated Probabilistic and Computational Framework for Analyzing 3D/4D Medical Images | Mansoura University, Egypt | 60 | prospective, observational | m-dixon, DWI, DTI, BOLD |
|
Dr Mohamed Abou El-Ghar |
|
Metabolic MRI in transplanted kidney
|
Uniklinik Duesseldorf, Germany | 40 | prospective, observational |
T2-HASTE, CEST
|
|