DISCLAIMER: This is an archive page describing a task force from the precursor project PARENCHIMA. The content is not up to date


Despite total kidney volume (TKV) having been approved as a prognostic enrichment biomarker, it has not been approved as outcome biomarker, yet, and additional evidence is required. Moreover, MRI offers a wide spectrum of microstructural/functional biomarkers which still needs to be investigated and validated in ADPKD.

This task force provides a central contact point for researchers with an interest in MRI for applications in Autosomal Dominant Polycystic Kidney Disease (ADPKD). The task force aims to improve the sharing of resources but will also aim to set up collaborative projects and prospective clinical studies in ADPKD involving MRI of the kidney.

Main aims:

  • Share expertise between the individual groups involved Apply for grant funding to further validate MRI biomarkers in ADPKD
  • Provide additional evidence for TKV as possible outcome biomarker
  • Go beyond TKV and investigate multiparametric MRI potential in ADPKD Explore the possibility for multiparametric multicentre/collaborative studies

Recent advances

Synergy with other PKD consortia

  • US PKD Outcome Consortium (PKDOC): on February 8th 2019 the task force presented its activities to PKDOC, during its monthly TC. If interested you can download the presentation here.
  • CYSTic - An international consortium to build a longitudinal observational cohort of patients with ADPKD Chief investigator: Prof. Albert Ong (University of Sheffield, UK) Multinational initiative (UK, Belgium, Germany, the Netherlands, France, Italy, Czech Republic, Spain)

Groups involved

People involved
Medical University of Vienna, Austria
Marcos Wolf
Universitair Ziekenhuis Brussel, Belgium
Patricia van der Niepen
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Janka Slatinska
Aarhus University Hospital, Denmark
Jens Dam Jensen, Christoffer Lautsen
Nephrology, Medical Imaging
Centre Hospitalier Universitaire (CHU) de Bordeaux, France
Nicolas Grenier
Charitè - Universitätsmedizin Berlin, Germany
Kai-Uwe Eckardt, Christian Rosenberger
Nephrology, Radiology
Heinrich-Heine-Universität Düsseldorf, Germany
Alexandra Ljimani
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy
Andrea Remuzzi, Anna Caroli, Norberto Perico, Giuseppe Remuzzi
MR imaging, Nephrology
Sapienza University, Rome, Italy
Silvia Lai, Sandro Mazzaferro, Anna Rita D’Angelo, Daniele Mastroluca, Marco Mangiulli
Private Health Institution- “Dr.Adamovski”, Bitola, Macedonia
Pavle Adamovski
Haukeland University Hospital, Bergen, Norway
Eli Eikefjord
Clinical Center of Vojvodina, Novi sad, Serbia
Olivera Nikolic
Lausanne University Hospital, Switzerland
Olivier Bonny
Geneve University Hospital, Switzerland
Jean-Paul Vallee, Lena Berchtold
Radiology, Nephrology
University Medical Centre Utrecht, the Netherlands
Peter Blankestijn
University of Sheffield, UK
Albert Ong, Rosylin Simms
Uppsala University Hospital, Sweden Per Liss Radiology
UCL London, UK
Fabio Nery, Isky Gordon
MR physics, Radiology

Task force leads

Lead: Prof. Andrea Remuzzi Vice-lead: Prof. Albert Ong

Pavle Adamovski Dr. Lena Berchtold Prof. Peter Blankestijn
Dr. Olivier Bonny Dr. Peter Boor Dr. Anna Caroli
Prof. Laustsen Christoffer Prof. Anna Rita D’Angelo Prof. Dr. Kai-Uwe Eckardt
Eli Eikefjord Prof. Isky Gordon Prof. Nicolas Grenier
Dr. Jens Dam Jensen Prof. Silvia Lai Dr. Per Liss
Dr. Alexandra Ljimani Dr. Marco Mangiulli Dr. Daniela Mastroluca
Prof. Sandro Mazzaferro Dr. Fabio Nery Prof. Dr. Olivera Nikolic
Prof. Albert Ong Dr. Norberto Perico Dr. Christian Rosenberg
Dr. Rosylin Simms Dr. Janka Slatinská Prof. Jean Paul Vallee
Dr. Marcos Wolf Dr. Patricia van der Niepen