Working group 3


WG3 overall objectives

Working group 3 joins up clinical sites working on renal MRI, and will pave the way for clinical use of renal MRI by addressing the need for stronger evidence in patients. 

The standardised methods developed in WG1 and WG2 will be used in large prospective multicentre clinical studies aimed at providing additional evidence of biological and clinical validity (against histopathology and reference methods) and clinical utility (prognostic value) of MRI biomarkers in renal disease.


WG3 short-term aims

  • Prepare the ground for a large scale longitudinal multicentre study aimed at providing additional evidence of biological and clinical validity of MRI biomarkers in CKD (look for fundings, draw up minimum standards for sites to participate in multicentre trials)

  • Explore grant funding to further validate MRI biomarkers in ADPKD

  • Explore grant funding to validate MRI biomarkers in renal transplantation

  • Coordinate smaller scale studies on specific relevant disease areas

  • Add MRI to ongoing renal initiative


WG3 achievements

  • Publication of an open access special issue on MRI biomarkers in renal disease in the journal Nephrol Dial Transplant, including an editorial, a position paper and 4 review papers (ASL, BOLD, DWI, T1&T2 mapping) providing a picture of the state of the art and practical recommendations. The special issue is free to view and download.

  • Creation of an ADPKD task force ( task force page), joining together all WG3 participants actively working in ADPKD MRI

  • Creation of a renal transplantation task force ( task force page), joining together all WG3 participants actively working in MRI in renal transplantation

  • Creation of a study document repository, containing study documents from past/ongoing clinical studies involving renal MRI, which could be helpful for designing new study protocols

  • Renal MRI dissemination in the radiology/nephrology communities 

  • Renal MRI ongoing multicenter clinical trials:

Study Clinical area Study type
Main info Principal investigator
iBEAt DKD Prospective, Observational Link
Prof. Steven Sourbron
HEROIC DKD Prospective, Observational Link

AFiRM CKD Prospective, Observational Link
Prof. Nicholas Selby
EMPA_KIDNEY
MRI sub-study
CKD Prospective, Interventional Link Prof. Richard Haynes


WG3 meetings

October 16th 2019, Nottingham, UK - WG3 session

October 4-5th 2018, Prague, Czech republic - WG3 yearly meeting (meeting page)

April 23rd 2018, Utrecht, The Netherlands - WG3 strategy meeting (meeting page)

October 13th 2017, Berlin, Germany - WG3 yearly meeting (meeting page)

July 13-14th 2017, Bergamo, Italy - WG3 kick-off meeting (meeting page)


WG3 contact information

If you need additional information, or in case you are interested in joining this effort, please contact the WG3 leads:

Anna Caroli (contact)

Nicholas Selby (contact)

Members

Working group 3 Lead: Dr Anna Caroli

Working group 3 Vice-Lead: Dr. Nicholas Selby