1.1 Technical recommendations on clinical renal MRI (OPEN)


Aims

This task force develops and maintains technical recommendations on how to measure renal MRI biomarkers on clinical scanners. If you are starting a clinical study, you will find here concrete guidelines on how to set up the acquisition, and you can be reassured that the approach will be accepted by a broad body of experts in the field. 

We expect this to lead to a significant improvement in efficacy of research by eliminating the need for local development and optimisation. It will also form a driver for a more standardised approach, improving comparability of results by different teams, and establishing a common benchmark to evaluate future developments.

The task force is led by Steven Sourbron (chair) and Pim Pullens (co-chair).


Status

A process for developing consensus-based recommendations has been defined, published and applied to Relaxometry, Diffusion, Arterial Spin Labelling and BOLD. Recommendations on Phase-Contrast MRI are in development. In the final year of PARENCHIMA, a process will be developed to update the recommendations and make compliant protocols available. We are currently setting up a Study Group on renal MRI within the International Society of Magnetic Resonance in Medicine (www.ismrm.org) with an aim to maintain the recommendations in the future. 


Process

Consensus formation in this task force follows a predefined process that is written out in an open access publication:

  • Mendichovszky, I., Pullens, P., Dekkers, I. et al. Technical recommendations for clinical translation of renal MRI: a consensus project of the Cooperation in Science and Technology Action PARENCHIMA. Magn Reson Mater Phy 33, 131–140 (2020). https://doi.org/10.1007/s10334-019-00784-w

The process includes the formation of expert panels for each MRI technique, who will develop an initial set of consensus statements (version 1.0) following a Delphi-like process and informed by a systematic review of the literature. After publication of version 1.0, the panels will remain in existence and update the recommendations if and when substantial new evidence emerges that justifies a new round of consensus formation. A process for generating these updates is currently in development. 


Recommendations

A version 1.0 of technical recommendations has been completed for renal ASL, DWI, T1 & T2 mapping, and BOLD. Results are reported in a special issue on renal MRI published by MAGMA in January 2020:

  • Nery, F., Buchanan, C.E., Harteveld, A.A. et al. Consensus-based technical recommendations for clinical translation of renal ASL MRI. Magn Reson Mater Phy 33, 141–161 (2020). https://doi.org/10.1007/s10334-019-00800-z
  • Ljimani, A., Caroli, A., Laustsen, C. et al. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI. Magn Reson Mater Phy 33, 177–195 (2020). https://doi.org/10.1007/s10334-019-00790-y
  • Dekkers, I.A., de Boer, A., Sharma, K. et al. Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI. Magn Reson Mater Phy 33, 163–176 (2020). https://doi.org/10.1007/s10334-019-00797-5
  • Bane, O., Mendichovszky, I.A., Milani, B. et al. Consensus-based technical recommendations for clinical translation of renal BOLD MRI. Magn Reson Mater Phy 33, 199–215 (2020). https://doi.org/10.1007/s10334-019-00802-x

Currently recommendations are in development for phase-contrast imaging of the renal arteries. As a first step, a systematic review paper is published in the special issue:

  • Villa, G., Ringgaard, S., Hermann, I. et al. Phase-contrast magnetic resonance imaging to assess renal perfusion: a systematic review and statement paper. Magn Reson Mater Phy 33, 3–21 (2020). https://doi.org/10.1007/s10334-019-00772-0

Protocols

The task force also collects detailed technical specifications of MRI acquisition protocols compliant with the recommendations. A Github repository is created to collect the protocols. A placeholder release of the repository was created in Zenodo when the recommendations were submitted and this will be updated with a new formal release once a more complete set is available.

If you have a protocol that is compliant with the recommendations, and would like to make it available through this repository, please follow the instructions provided in the Github repository page.


Updating of recommendations

We are currently working on a process for updating the recommendations in light of new evidence. 


Expert panels

The role of the expert panel is to develop recommendations for individual methods, review submitted protocols for compliance with the recommendations, and review requests for new recommendations or updates of existing recommendations. The panels are open to participation of any expert with a track record in the relevant field. If you want to join a panel, please contact the panel chair.


ASL Panel

  • Chair: Maria Seara (Pamplona, Spain)
  • Co-chair: Fabio Nery (London, UK)
  • Anita Harteveld (Utrecht, The Netherlands)
  • Susan Francis (Nottingham, UK)
  • Xavier Golay (London, UK): 5 (major contribution in defining the approach to consensus formation)
  • Alexandra Ljimani (Dusseldorf, Germany)
  • Katja Derlin (Hannover, Germany)
  • Charlotte Buchanan (Nottingham, UK)
  • Eleanor Cox (Nottingham, UK)
  • David Alsop (Boston, US)
  • Ivan Pedrosa (Dallas, US)
  • Ananth Madhuranthakam (Dallas, US)
  • Danny JJ Wang (USC, Los Angeles)
  • Agogho Odudu (Manchester, UK)
  • Philip Robson (Mount Sinai, US)
  • Jeff Zhang (Utah, US)
  • Kanishka Sharma (Leeds, UK)
  • Michael Gach (Washington University, St. Louis, USA)
  • Manuel Taso (Beth Israel Deaconess Medical Center, Boston, USA)
  • David Thomas (UCL, London, UK)
  • Marcel Gutberlet (Hannover Medical School, Germany)
  • Pim Pullens (Gent, Belgium)
  • Steven Sourbron (Sheffield, UK)

BOLD Panel

  • Chair: Pottumarthi Prasad (Northshore, US)
  • Co-chair: Octavia Bane (Mount Sinai, US)
  • Menno Pruijm (Lausanne, Switzerland)
  • Lilach Lerman (Rochester, Minnesota, US)
  • Iosif Mendichovszky (Cambridge, UK)
  • Susan Francis (Nottingham, UK)
  • Stephen Textor (Rochester, US)
  • Bastien Milani (Lausanne, Switzerland)
  • Sean Fain (Wisconsin, US)
  • Chunlei Liu (Berkeley, US)
  • Kanishka Sharma (Leeds, UK)
  • Christoffer Laustsen (Aarhus, DK)
  • Thoralf Niendorf (Berlin, Ger)
  • Jeff Zhang (Utah, US)
  • Andreas Pohlmann (Berlin, Ger)
  • Pim Pullens (Gent, Belgium)
  • Steven Sourbron (Sheffield, UK)

DWI Panel

  • Chair: Eric Sigmund (New York, USA)
  • Co-chair: Alexandra Ljimani (Dusseldorf, Germany)
  • Nicolas Grenier (Bordeaux, France)
  • Iosif Mendichovszky (Cambridge, UK)
  • Jean-Paul Vallee (Geneva, Switzerland)
  • Anna Caroli (Bergamo, Italy)
  • Harriet Thoeny (Fribourg, Switzerland)
  • Susan Francis (Nottingham, UK)
  • Katja Derlin (Hannover, Germany)
  • Marcos Wolf (Vienna, Austria)
  • Martijn Froeling (Utrecht, The Netherlands)
  • Kanishka Sharma (Leeds, UK)
  • Moritz Schneider (Munich, Germany)
  • Christoffer Laustsen (Aarhus, DK)
  • Thoralf Niendorf (Berlin, Ger)
  • Fabio Nery London, UK)
  • Pim Pullens (Gent, Belgium)
  • Steven Sourbron (Sheffield, UK)

T1&T2 Panel

  • Chair: Susan Francis (Nottingham, UK)
  • Co-chair: Ilona Dekkers (Leiden, NL)
  • Marcos Wolf (Vienna, Austria)
  • David Buckley (Leeds, UK)
  • Jo Naish (Manchester, UK)
  • Charlotte Buchanan (Nottingham, UK)
  • Eleanor Cox (Nottingham, UK)
  • Anneloes de Boer (Utrecht, The Netherlands)
  • Kanishka Sharma (Leeds, UK)
  • Christoffer Laustsen (Aarhus, DK)
  • Matthew Robson (Oxford, UK)
  • Hildo Lamb (Leiden, NL)
  • Pim Pullens (Gent, Belgium)
  • Steven Sourbron (Sheffield, UK)

Phase-contrast Panel

  • Chair: Anna Caroli (Bergamo, Italy)
  • Co-chair: Anneloes de Boer (Utrecht, the Netherlands)
  • Fabio Nery (London, UK)
  • Giulia Villa (Bergamo, Italy)
  • Octavia Bane (New York, USA)
  • Michael Bock (Freiburg, Germany)
  • Eleonor Cox (Nottingham, UK)
  • Ilona Dekkers (Leiden, the Netherlands)
  • Per Eckerbom (Uppsala, Sweden)
  • Maria Fernandez Seara (Pamplona, Spain)
  • Susan Francis (Nottingham, UK)
  • Bryan Haddock (Glostrup, Denmark)
  • Michael Hall (Jackson, USA)
  • Pauline Hall Barrientos (Glasgow, UK)
  • Ingo Hermann (Mannheim, Germany)
  • Paul Hockings (Goteborg, Sweden)
  • Hildo Lamb (Leiden, the Netherlands)
  • Christoffer Laustsen (Aarhus, Denmark)
  • Ruth Lim (Melbourne, Australia)
  • David Morris (Edinburgh, UK)
  • Steffen Ringgaard (Aarhus, Denmark)
  • Suraj Serai (Philadelphia, USA)
  • Kanishka Sharma (Sheffield, UK)
  • Steven Sourbron (Sheffield, UK)
  • Yasuo Takehara (Nagoya, Japan)
  • Andrew Wentland (Stanford, USA)
  • Marcos Wolf (Vienna, Austria)
  • Frank Zoellner (Heidelberg, Germany)