Magnetic Resonance Fingerprinting for simultaneous renal T1 and T2* mapping in a single breath-hold

link to publication: https://onlinelibrary.wiley.com/doi/epdf/10.1002/mrm.28160

Authors:
I. Hermann, J. Chacon-Caldera, I. Brumer, B. Rieger, S. Weingärtner, L. Schad and F. Zöllner

Contact:
frank.zoellner (@) medma.uni-heidelberg.de

Abstract

Purpose
To evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of T1 and T2* in a single breath‐hold in the kidneys.
Methods
The proposed kidney MRF sequence was based on MRF echo‐planar imaging. Thirty‐five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in‐line quantification of T1 and T2* Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the T1 and T2* times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability.
Results
T1 and t2* times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for T1 and less than 10% forT2*. Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation T1:7 ± 4%, T2*: 6 ± 3%).
Conclusions
In this feasibility study, the proposed renal MRF sequence resulted in accurate T1 and T2* quantification in a single breath‐hold.

This publication is linked to Working Group 2

Posted on donderdag 20 februari 2020