Inventory of clinical studies in renal MRI

This inventory provides a list of ongoing or completed clinical studies involving MRI of the kidney. The list was compiled by PARENCHIMA working group 3 (https://renalmri.org/workgroup/3) and continues to be maintained. Initial data were collected from working group members and through individual contact with external researchers. The inventory is dynamic and will continue to be updated and maintained as new studies are started, or ongoing studies are closed.

**The inventory is currently being revised to include the most up to date information. For ongoing studies, investigators are asked to provide a clinical trial registration number and/or a link to a published study protocol. For studies that are not yet recruiting, a link to the award is sufficient. For completed studies, investigators will be asked to provide a link to a publication reporting on the primary outcome. Studies that are not able to provide these informations will be removed from the inventory. **

For any comments, corrections or additions, please refer to the following contacts:

Notations used:

  • P = Prospective, R = Retrospective
  • O = Observational, I = Interventional


Ongoing multi-centre studies (excluding ADPKD and Transplantation)


Study name Clinical area N. patients Study type Protocol / registration Principal investigator/ Contact person
iBEAt DKD 500 T2D, 50 T1D  P, O Protocol paper Prof. Steven Sourbron
HEROIC DKD 500 P, O
Protocol paper Dr Kieran Mccafferty
AFiRM CKD 450 P, O Award Prof. Nicholas Selby
EMPA_KIDNEY
MRI sub-study
CKD 60 P, I Registration Prof. Richard Haynes
DWI for kidney cortical intersitial fibrosis prediction Renal transplantation 250 P, O MISSING Prof Jean-Paul Vallee


Ongoing single-centre studies (excluding ADPKD and Transplantation)


Study Clinical area N. patients Study type Main
info
Principal investigator/
Contact person
SUGAR Heart failure, Diabetes 105 Prospective, Interventional (Empagliflozin) Link Prof. Naveed Sattar
AM-01 DKD 66 Prospective, Observational
Dr Seema Baid-Agrawal
Dr Paul Hockings
Advanced MRI for improved diagnosis and prediction of treatment response in Wilms’ tumour patient Wilms' tumour 110 Prospective, Observational
Dr Chris Clark
Renal diffusion in CKD CKD 150 Prospective, Observational
Dr Jean-Paul Vallée
ReMARK Healthy volunteers 20 Prospective, Observational
Dr Anneloes de Boer
ReFINED CKD, hypertension, healthy volunteers 10/10/15 Prospective, Observational
Dr Anneloes de Boer
Role of digital pathology and MRI in the early detection of interstitial fibrosis in CKD CKD (both native and transplanted kidneys) 75 Prospective, Observational
Dr Carlos Nicolau
Gender-BOLD CKD and controls 110 Prospective, Observational
Dr Menno Pruijm
Functional MRI in the diagnostics of diabetic nephropathy in patients with type 2 DM DKD 90 Prospective, Observational
Dr Olivera Nikolic
ACH471-205
MRI sub-study
C3G -
IC-MPGN rare disease
7 Prospective, Interventional (ACH-0144471) Link Dr Anna Caroli
ROCKIES Diabetes 40 (T2D and healthy controls) Prospective, Interventional
(Ertugliflozin)
Link Dr Daniel van Raalte
GCKD MRI sub-study CKD 30 prospective, observational
Prof. Dr. K. U. Eckardt / Dr. Maurice Heimer
Improvement of diagnostics of myeloma specific renal changes by functional MRI-biomarkers multiple myeloma 40 patients, 10 healthy volunteers prospective, observational
Dr Alexandra Ljimani
Renal pathologies in rheumatological diseases: Improvement of diagnostics using functional magnetic resonance imaging Lupus 30 prospective, observational
Dr Alexandra Ljimani
Quantitative magnetization transfer MRI for evaluation of renal fibrosis Renovascular disease 15 prospective, observational Link Prof. Lilach O. Lerman
Advanced diffusion imaging for management of renal cancer: oncologic control and renal functional reserve Renal cancer 24 healthy controls, 150 renal mass patients  prospective, observational Link Dr Eric Sigmund
Dr Hersh Chandarana 
Role of MMP-10 and tissue perfusion in diagnosis and prognosis of renal and cardiovascular disease in patients with 2 type diabetes mellitus Diabetes 70 with MRI (268 in total) prospective, observational
Dr Nuria García Fernández
Quantitative susceptible imaging of the human kidney on a clinical MRI system Mixed 20 renal patients, 10 healthy volunteers prospective, observational
Dr Alexandra Ljimani
Evaluation of CT-contrast agent induced ATN by functional renal MR-imaging CT-contrast agent induced ATN 40 prospective, observational
Dr Alexandra Ljimani
Evaluation of renal damage after a SARS-CoV-2 infection using functional, contrast-free kidney MRI COVID-19 30 prospective, observational
Dr Alexandra Ljimani


Completed studies (excluding ADPKD and Transplantation)


Study Clinical area N. patients Study type Main
info
Principal investigator/
Contact person
REMIND-CKD CKD 26 prospective, observational Link Prof. Nicholas Selby
REMIND-AKI AKI 10 prospective, observational
Prof. Nicholas Selby
Effects of the SGLT-2 Inhibitor Empagliflozin on Renal Tissue Oxygenation in Non-Diabetic Subjects: A Randomized, Double-Blind, Placebo-Controlled Study Protocol. healthy volunteers (non-diabetic subjects) 15 normal weight, 15 overweight, 15 obese prospective, interventional (Empagliflozin) Link Dr Menno Pruijm
Renal NCE-MRI in Healthy Volunteers healthy volunteers 16 prospective, observational Link Dr Anna Caroli
Renal DCE-MRI in healthy volunteers comparing two imaging sequences (FLASH/KWIC) and use of iohexol clearance as clinical reference test healthy volunteers 10 prospective, observational
Dr Eli Eikefjord
Test-retest renal DCE-MRI in healthy volunteers and use of iohexol clearance as clinical reference test healthy volunteers 20 prospective, observational
Dr Eli Eikefjord
Renal DCE-MRI in living kidney donors Kidney donors 20 prospective, observational
Dr Eli Eikefjord
Renal pCASL Repeatability/Reproducibility Study healthy volunteers 10 prospective, observational
Dr Doug Pendse
MRI in healthy volunteers healthy volunteers 7 prospective, observational
Dr Isky Gordon
MRI reproducibility in healthy volunteers healthy volunteers 16 prospective, observational
Dr Isky Gordon
MRI in paediatric CKD paediatric CKD 11 prospective, observational
Dr Isky Gordon
Reproducibility of Single Kidney GFR with DCE-MRI in healthy volunteers healthy volunteers 34 prospective, observational
Dr Isky Gordon
DWI in healthy volunteers healthy volunteers 10 prospective, observational
Dr Paul Summers
DCE-MRI in renal pathology mixed renal pathology 30 prospective, observational
Dr Paul Summers
Renden resistant hypertension 75 prospective, observational
Dr Anneloes de Boer
EnCORED: renal artery and parenchymal changes after RDN therapy resistant hypertension 96 prospective, interventional (RDN)
Dr Anneloes de Boer
Influence of RAAS inhibition; determine the influence of RAAS inhibition on kidney oxygenation CKD, healthy volunteers 10 CKD patients, 5 healthy volunteers prospective, interventional (RAAS inhibitors)
Dr Anneloes de Boer
LauBOLD CKD, hypertension, healthy volunteers 224 prospective, observational
Dr Menno Pruijm
4R01DK093793-05: Longitudinal Changes in the Intra-Renal Oxygenation by BOLD MRI in patients with CKD CKD, healthy 66 prospective, observational Link Dr Pottumarthi Prasad
5R21DK079080-02: The intra-renal oxygenation in CKD as evaluated by BOLD-MRI CKD, healthy 45 cross-sectional, observational Link Dr Pottumarthi Prasad
CKD Optimal Management with Binders and Nicotinamide
(COMBINE)
CKD 122 prospective, interventional (nicotinamide and lanthanum carbonate) Link Dr Anand Srivastava
Role of MMP-10 and tissue perfusion in nephropathy associated to type 2 diabetes mellitus: clinical and experimental study Diabetes 45 controls and 44 T2DM patients with MRI (111 and 268 in total) prospective, observational Dr Nuria García Fernández


Ongoing studies in ADPKD


Study Center N patients Study type MR sequences (besides anatomical) Main info Contact person
MR-Progression-Evaluation of Chronic Kidney Disease Medical University of Vienna, Austria 90 early stage ADPKD, 30 healthy controls Observational T1&T2 mapping, DWI/DTI, MRE DRKS-ID: DRKS00015866 Dr Marcos Wolf
Functional MRI in ADPKD Universitair Ziekenhuis Brussel, Belgium 30

Observational DCE
Dr Patricia van der Niepen
PKD – imaging the genomic derangements with ultra-sensitive metabolic MRI Aarhus University Hospital, Denmark 40 Interventional spsp-SPIRAL, T1&T2 mapping, DWI, BOLD, pCASL
Dr Christoffer Laustsen
Multiparametric MRI to detect, quantify and predict prognosis of ADPKD Haukeland University Hospital/University of Bergen, Norway 30 ADPKD patients, 12 non-ADPKD subjects Observational DWI/DTI, BOLD, T1&T2 mapping, ASL
Dr Eli Eikefjord
TOOL Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy 20 Interventional (Tolvaptan Plus Octreotide LAR Combination) DWI, PC-MRI Link Dr Anna Caroli
Renal fibrosis, microRNA and cardiovascular risk in ADPKD: effect of tolvaptan therapy Sapienza University, Rome, Italy 30+30 Interventional (Tolvaptan) DCE
Dr Silvia Lai
STAGED-PKD 77 centers (USA, Japan, Germany/Austria) 640 Interventional (venglustat)
EudraCT number: 2017-004084-12
Link
Sanofi
Imaging to define disease progression in ADPKD University of Sheffield and Sheffield Kidney Institute, Sheffield, UK 35 prospective, observational

Dr Rosylin Simms


Completed studies in ADPKD


Study Center N. patients Study type MR sequences (besides anatomical) Main
info
Contact person
EUROCYST 13 centers around Europe
(DWI substudy: Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy)
~ 600
(DWI subgroup - 15)
prospective, observational anatomical (all patients),
DWI (subgroup)
Link Dr Anna Caroli (DWI subgroup)
Functional kidney MRI to identify novel biomarkers of disease progression in ADPKD University of Sheffield and Sheffield Kidney Institute, Sheffield, UK 29 prospective, observational T2*, DWI, DTI, PC-MRI
Dr Rosylin Simms
Hyperaldosteronism and cardiovascular risk in patients with autosomal dominant polycystic kidney disease

Sapienza, University of Rome, UOC Nephrology,
Policlinico Umberto I Hospital
27 prospective, observational DCE-MRI
Dr Silvia Lai
Magnetic resonance imaging 3T and total fibrotic volume in autosomal dominant polycystic kidney disease. Sapienza, University of Rome, UOC Nephrology,
Policlinico Umberto I Hospital
15 prospective, observational DCE-MRI
Dr Silvia Lai


Ongoing studies in Transplantation


Study Center N. Patients Study type MR sequences (besides anatomical) Main info Contact person
Risk factor evaluation for inferior outcome after kidney transplantation by assessment of renal pathophysiology with functional MRI in correlation with molecular markers
Hannover Medical School, Germany
26
observational
T2 TSE, T1, ASL, DWI, DTI, T1-Map

Artificial intelligence-based analysis of MRI biomarkers to detect allograft dysfunction after kidney transplantation
Hannover Medical School, Germany
200
observational
T2 TSE, T1, ASL, DWI, DTI, T1-Map, BOLD

Longitudinal evaluation of renal allograft function after transplantation using ASL and IVIM
Clínica Universidad de Navarra, Spain
40 transplanted patients, 20 controls (eGFR>60) 
observational
T1 VIBE, T2 HASTE, ASL, IVIM


TransRASL
University of Glasgow, UK
20
observational
T1 Map, ASL, T2*, DWI, DTI

diffusion MRI for kidney cortical intersitial fibrosis prediction University of Geneve, Switzerland 246 (both native and transplant) observational RESOLVE (DWI), T1, T2
Dr Jean-Paul Vallee
ACRADYS University Medical Center Utrecht, the Netherlands 50 observational BOLD, ASL, DTI
Dr Anneloes de Boer
Multicentric Study of diffusion MRI for kidney cortical intersitial fibrosis prediction University of Geneve. University of Lausanne, Fribourg Hospital; Switzerland 250 observational RESOLVE (DWI), T1, T2
Dr Jean-Paul Vallee, Dr Menno Pruijm, Prof Harriet Thoeny
Artificial intelligence-based analysis of MRI biomarkers to detect allograft dysfunction after kidney transplantation
Hannover Medical School, Germany; University Medical Center Groeningen, the Netherlands
200 renal transplant patients, 50 living donors
observational
ASL, DWI, IVIM, DTI, T1/T2 mapping, BOLD

Noninvasive Evaluation of Renal Allograft Fibrosis by MRI Kidney transplant recipients 20 prospective, observational MT, B1, B0, T1 mapping, DWI, BOLD, and ASL
Prof. Lilach O. Lerman


Completed studies in Transplantation


Study Center N. patients Study type MR sequences (besides anatomical) Main
info
Contact person
Donor transplant assessment Institute of Child Health, London, UK 8 prospective, observational ASL, BOLD, DWI, T1
Dr Isky Gordon
Longitudinal study of children following renal replacement therapy Institute of Child Health, London, UK 20 prospective, observational ASL, BOLD, DWI, T1
Dr Isky Gordon
Observational study in renal transplants University of Glasgow, UK 20 prospective, observational ASL, T1, DTI, BOLD
Dr Paddy Mark
Biexponential analysis of DWI: comparison of three different calculation methods in transplanted kidneys Uniklinik Duesseldorf Germany 15 prospective, observational DWI Link
Correlation of biexponential diffusion parameters with ASL perfusion MRI: results in transplanted kidneys Uniklinik Duesseldorf Germany 17 prospective, observational DWI, ASL Link
Kidney transplant: functional assessment with DTI at 3T Uniklinik Duesseldorf Germany 40 prospective, observational DTI Link
Diffusion-attenuated MRI signal of renal allografts: comparison of two different statistical models Uniklinik Duesseldorf Germany 23 prospective, observational DWI/DTI Link
T2' Imaging of Native Kidneys and Renal Allografts - a Feasibility Study Uniklinik Duesseldorf Germany 24 prospective, observational T2 mapping Link
Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results Uniklinik Duesseldorf Germany 20 prospective, observational T2 mapping, ASL Link
Functional MRI of transplanted kidneys using diffusion-weighted imaging Uniklinik Duesseldorf Germany 41 prospective, observational DWI
Functional multiparametric MRI in delayed graft function after kidney Transplantation Hannover Medical School 70 prospective, observational ASL, DWI, DTI, T2 mapping
Integrated Probabilistic and Computational Framework for Analyzing 3D/4D Medical Images Mansoura University, Egypt 60 prospective, observational m-dixon, DWI, DTI, BOLD
Dr Mohamed Abou El-Ghar
Metabolic MRI in transplanted kidney
Uniklinik Duesseldorf, Germany 40 prospective, observational
T2-HASTE, CEST

Posted on January 25, 2021 11:31