Diabetic nephropathy is often diagnosed inadequately and, therefore, treatment is delayed. Early detection of diabetic nephropathy is crucial because it allows the prompt application of therapeutic procedures aimed at preserving the remaining healthy nephrons and the prevention of terminal renal failure. This is what motivated me and my PhD student to start the project MRI biomarkers in the assessment of renal function in patients with type 2 diabetes mellitus.
The advantage of functional MRI examination of the kidney is to provide information about the functioning of each kidney separately, in the early stage of the disease, without the use of intravenous contrast and exposure to radiation. Functional MRI scan techniques DTI and DWI would allow early detection of functional changes in the kidney, potentially replacing the invasive biopsy of the kidney parenchyma. Functional MRI examination neither prolongs significantly duration of the examination nor requires special preparation of patients, additional application of medicines and, therefore, is a potentially safe method.
To prove that quantitative values of fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) can be used as early biomarkers to evaluate renal function in patients with type 2 diabetes mellitus. This technique can be simply implemented into a routine abdominal MRI protocol, with a small increase of scanning time.