PURPOSE OF THE STSM
Renal Magnetic Resonance Elastography (MRE) is a novel approach that holds the promise the assess renal interstitial fibrosis directly, which could be used as a bio-marker with regards to chronic kidney disease (CKD). But measuring native kidneys in vivo remains a challenge, which is also observed on liver applications (Wagner et al. 2017).
Ralph Sinkus and his team at the King's College London (KCL) have proposed a new 'gravitational' transducer, together with a sophisticated MRE sequence and post processing software, which have the highly promising potential to improve renal MRE on native kidney (Garteiser et al. 2013).
The goal of this application is to gain firsthand experience on the novel gravitational transducer and the associated MRE sequence as well as the post processing software. Together with the KCL-Team we want to set up a first preliminary study protocol to evaluate the performance between the envisioned system at the KCL and the system in Vienna (pneumatic transducer) (Venkatesh,Yin, and Ehman 2013).
3.Proposed contribution to the scientific objectives of the Action
A direct measurement of the mechanical properties of native kidneys can pave the way to assess renal interstitial fibrosis directly, which could be translated into a biomarker for chronic kidney disease in the clinical practice (Marticorena Garcia et al. 2016).
The proposed novel gravitational transducer uses a rotational eccentric mass, which creates a low-frequency vibrational wave without significant impurities (e.g. no significant upper harmonics compared to a pneumatic transducer). These shear waves are captured with an inhouse programmed phase sensitive Spin Echo MRE sequence. Thereafter an inhouse post processing software is used to evaluate the stiffness.
Garteiser, Philippe, Ramin S. Sahebjavaher, Leon C. Ter Beek, Septimiu Salcudean, Valérie Vilgrain, Bernard E. Van Beers, and Ralph Sinkus. 2013. “Rapid Acquisition of Multifrequency, Multislice and Multidirectional MR Elastography Data with a Fractionally Encoded Gradient Echo Sequence.” NMR in Biomedicine 26 (10):1326–35.
Marticorena Garcia, Stephan Rodrigo, Thomas Fischer, Michael Dürr, Emin Gültekin, Jürgen Braun, Ingolf Sack, and Jing Guo. 2016. “Multifrequency Magnetic Resonance Elastography for the Assessment of Renal Allograft Function.” Investigative Radiology 51 (9):591–95.
Venkatesh, Sudhakar K., Meng Yin, and Richard L. Ehman. 2013. “Magnetic Resonance Elastography of Liver: Technique, Analysis, and Clinical Applications.” Journal of Magnetic Resonance Imaging: JMRI 37 (3):544–55.
Wagner, Mathilde, Idoia Corcuera-Solano, Grace Lo, Steven Esses, Joseph Liao, Cecilia Besa,Nelson Chen, et al. 2017. “Technical Failure of MR Elastography Examinations of the Liver: Experience from a Large Single-Center Study.” Radiology 284 (2):401–12.
Action Number 40219