University of Leeds, United Kingdom - Apr. 23-28, 2018
Report

WG1: MRI (DWI,DTI) biomarkers for DM type II (closed)

Motivation

Diabetic nephropathy is often diagnosed inadequately and, therefore, treatment is delayed. Early detection of diabetic nephropathy is crucial because it allows the prompt application of therapeutic procedures aimed at preserving the remaining healthy nephrons and the prevention of terminal renal failure. This is what motivated me and my PhD student to start the project MRI biomarkers in the assessment of renal function in patients with type 2 diabetes mellitus.

The advantage of functional MRI examination of the kidney is to provide information about the functioning of each kidney separately, in the early stage of the disease, without the use of intravenous contrast and exposure to radiation. Functional MRI scan techniques DTI and DWI would allow early detection of functional changes in the kidney, potentially replacing the invasive biopsy of the kidney parenchyma. Functional MRI examination neither prolongs significantly duration of the examination nor requires special preparation of patients, additional application of medicines and, therefore, is a potentially safe method.

Aim

  1. To correlate and optimize our and host institution protocol of the functional magnetic resonance imaging examination of the kidneys in patients with type 2 diabetes mellitus
  2. To learn how post processing and tractography are performed in the host institution
  3. To discuss how to standardize ADC and FA numerical values

Conclusion

To prove that quantitative values of fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) can be used as early biomarkers to evaluate renal function in patients with type 2 diabetes mellitus. This technique can be simply implemented into a routine abdominal MRI protocol, with a small increase of scanning time.